Gastroenterology

Canadian Organizations Gather Stakeholders to Stimulate Biosimilar Acceptance

December 18th 2019

By The Center for Biosimilars Staff

The pan-Canadian Pharmaceutical Alliance engaged the Canadian Agency for Drugs and Technologies in Health to lead a multiphase stakeholder consultation process to encourage biosimilar uptake.

Proactively Versus Reactively Measuring CT-P13 Trough Levels Did Not Improve 1-Year Outcomes in IBD

December 9th 2019

As yet, there exists no consensus as to whether proactive or reactive monitoring is the most appropriate approach in patients with inflammatory bowel disease (IBD) who receive infliximab therapy.

More Evidence Supports Introducing Adalimumab Early in Patients With CD

December 3rd 2019

By The Center for Biosimilars Staff

In Crohn disease (CD), anti–tumor necrosis factor therapies like adalimumab have provided an alternative to long-term corticosteroid therapy and have reduced the need for many patients to have surgical interventions. It has been proposed that early treatment with biologics may lead to better outcomes and fewer complications—like strictures and fistulae—and findings from a recent study support that assertion.

New Data Help Delineate the Role of Biosimilar Infliximab and JAK Inhibitors in Pediatric IBD

November 29th 2019

By Kelly Davio

Data on the safety and efficacy of biosimilar infliximab CT-P13 (Inflectra, Remsima) in treating inflammatory bowel disease (IBD) continue to accrue, in both adult patients and in pediatric patients, and a study from Finland adds to that body of knowledge, while another study in pediatric patients shows that Janus kinase (JAK) inhibitors may be an option for those who do not respond adequately to infliximab or other biologic treatment.

Mandated Switching to Biosimilars Begins in British Columbia, May Spread to Other Provinces

November 27th 2019

By The Center for Biosimilars Staff

The issue of whether to switch patients currently taking biologics to biosimilars has been playing out in Canada over the past week, as mandated switching begins in British Columbia, while a reference product maker fights against a possible similar change in 2 other provinces.

Subcutaneous Formulation of Celltrion's Biosimilar Infliximab Authorized by European Commission

November 26th 2019

By Kelly Davio

Celltrion Healthcare announced that the European Commission has authorized Remsima SC, a subcutaneously administered formulation of its biosimilar infliximab, CT-P13, for the treatment of rheumatoid arthritis. The product is the first subcutaneous infliximab option to be approved in any regulatory territory.

More Data Needed on Using Biologics in Children, Review Says

November 18th 2019

By Allison Inserro

A recent review explored the evidence of monoclonal antibodies (mAb) and fusion proteins (FP) to examine their safety and efficacy in the most common chronic inflammatory diseases in children—bronchial asthma, psoriasis, juvenile idiopathic arthritis (JIA), and chronic inflammatory bowel diseases (IBD).

Benjamin Click, MD: Route of Administration and Patient Adherence to IBD Therapy

November 6th 2019

Benjamin Click, MD, staff gastroenterologist, the Cleveland Clinic, discusses how route of administration impacts patient adherence to inflammatory bowel disease (IBD) therapy.

"Not So Different": What's New in Biosimilars in Gastroenterology

November 3rd 2019

With new research being presented, and with new biosimilars in the pipeline that target inflammatory bowel disease, October was a notable month for biosimilars in the gastroenterology space. This week on the podcast, we’re rounding up the top developments in gastroenterology for the month of October 2019.

Biosimilar Infliximab Associated With Improved PROs in IBD for New Starts, Switched Patients

November 1st 2019

By Kelly Davio

The ONWARD study included patients who initiated therapy with the biosimilar, those who switched from the reference infliximab, or those who switched from a different biologic therapy.